Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

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Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections.

An acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to d...

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ژورنال

عنوان ژورنال: Acta Pharmaceutica

سال: 2008

ISSN: 1846-9558,1330-0075

DOI: 10.2478/v10007-008-0023-2